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These designs allow for the comparison of behavior before and after an intervention, providing valuable insights into the impact of treatments. During this period, the dependent variable is measured repeatedly under control conditions. The active ingredient in the intervention, incentives contingent on objectively verified smoking abstinence, was not introduced until the treatment phase. SCDs include an array of methods in which each participant, or case, serves as his or her own control. Although these methods are conceptually rooted in the study of cognition and behavior [14], they are theory-neutral and can be applied to any health intervention.
Mitigating Risks for Children with Autism
In light of the limitations of traditional designs and advances in data collection methods, a growing number of researchers have advocated for alternative research designs [2, 7, 10]. Specifically, one family of research designs, known as single-case designs (SCDs), has been proposed as a useful way to establish the preliminary efficacy of health interventions [3]. In the present article, we recapitulate and expand on this proposal, and argue that they can be used to optimize health interventions. Withdrawal designs, also known as ABAB designs, rely on the comparisons between conditions when an intervention is in place and conditions when that intervention is not being implemented.
AMB Designs
This search yielded more than 12,000 results, which the second author would hand search in order until she had identified 500 graphs. After identifying 150 graphs, we conducted a second search to improve efficiency as the second author had not identified relevant graphs in more than 60 consecutive theses and dissertations. This second search used the keywords ABAB combined with “single case.” This strategy generated approximately 1100 results.
Typology of single-case experimental designs
These designs provide strong internal validity evidence regarding the effectiveness of the interventions. External validity, however, may be compromised by the threat of multiple-treatment interference. Additionally, the same advantages and disadvantages of ABAB designs apply, including issues related to the reversibility of the target behavior. Despite their limitations, these designs can provide strong empirical data upon which to base decisions regarding the selection of treatments for an individual client. Although, in theory, these types of designs can be extended to compare any number of interventions or conditions, doing so beyond two becomes excessively cumbersome; therefore, the alternating treatments design should be considered.

We also describe how SCDs can address other features of optimization, which include establishing generality and enabling personalized behavioral medicine. Throughout, we highlight how SCDs can be used during both the development and dissemination stages of behavioral health interventions. ABA therapy has been widely researched and has demonstrated effectiveness in improving various skills and reducing challenging behaviors in individuals with autism. ABA therapy can be tailored to the unique needs of each individual and is often implemented in various settings, such as homes, schools, and clinics.
By reversing the intervention and observing the corresponding changes in behavior, ABAB design provides strong evidence of internal validity. The repeated alternation between intervention and baseline phases allows researchers to establish a clear cause-and-effect relationship between the independent variable and the dependent variable. Because of their efficiency and rigor, SCDs permit systematic replications across types of participants, behavior problems, and settings. This research process has also led to “gold-standard,” evidence-based treatments in applied behavior analysis and education [29, 79]. More importantly, in several fields, such research has led to scientific understanding of the conditions under which treatment may be effective or ineffective [79, 80]. The field of applied behavior analysis, for example, has matured to the extent that individualized assessment of the causes of problem behavior must occur before treatment recommendations.
It is possible that randomized AB phase designs with fewer than 60 measurement occasions may also have sufficient power in specific conditions we simulated, but we cannot verify this on the basis of the present results. As we previously mentioned, we do not recommend implementing randomized AB phase designs with more than 60 measurement occasions, since the extra practical burden this entails does not outweigh the very small increase in power it yields. In this article we have argued that randomized AB phase designs are an important part of the methodological toolbox of the single-case researcher.
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These designs have also been used to investigate other behaviors relevant to applied behavior analysis. Response to verbal elicitation protocols in children with autism has been studied using ABAB designs, providing insights into the effectiveness of interventions in improving communication skills [4]. To determine the right design for your needs, carefully evaluate the factors discussed above. Consider the research question, behavior complexity, desired level of experimental control, available resources, sample size, and ethical considerations.
In addition to Applied Behavior Analysis (ABA) design, another commonly used experimental design in the field of behavior analysis is ABAB design. This design is characterized by its alternating pattern of baseline and intervention phases, providing valuable insights into the effectiveness of interventions for individuals with autism and other behavioral challenges. The ABAB design is a research design commonly used in applied behavior analysis (ABA) to evaluate the effectiveness of interventions for individuals with autism. This design allows for the systematic assessment of the impact of a specific intervention by alternating between periods of baseline and intervention phases. Designs such as ABCABC and ABCBCA can be very useful when a researcher wants to examine the effects of two interventions.
By evaluating the behavior in both the presence and absence of the intervention, the ABAB design helps identify the most effective intervention without having to start the entire process from scratch. It offers stronger evidence of the effectiveness of a treatment, as changes in behavior can be attributed to the introduction and removal of the intervention [2]. This evidence-based approach is essential in determining the most successful intervention methods. Following the initial analysis, we calculated three measures of effect sizes for each dataset and examined to what extent each measure could predict the replication of the effects observed in the initial AB component.
A baseline is established for several participants and the treatment is then introduced to each participant at a different time. The dependent variable ranges between 12 and 16 units during the baseline, but drops down to 10 units with treatment and mostly decreases until the end of the study, ranging between 4 and 10 units. An example cited in one article is that of children asked to read a paragraph that included text only. Finally, they were given another paragraph that contained only text and retested to see if their grasp of the information returned to the initial test results. Using the ABA design, the therapist can evaluate the effects of treatment related to baseline responding.

Meanwhile, single data collection sessions would be conducted in each of the other conditions to assess pre-intervention levels. Once responding has reached the criterion threshold in the intervention phase of the first leg, continuous measurement of pre-intervention levels is introduced in the second. When stable responding during the intervention phase is observed, intermittent probes can be implemented to demonstrate continued performance, and intervention is introduced in the second leg. This pattern is repeated until the effects of the intervention have been demonstrated across all the conditions.
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